中文同义词:
去屑剂;吡罗克酮乙醇铵;1-羟基-4-甲基-6-(2,4,4-三甲苯基)吡啶酮乙醇胺复合盐;吡罗克酮 乙醇胺盐;吡啶酮乙醇胺盐(去屑剂OCTO);吡啶酮乙醇胺盐;羟吡酮;罗酮奥拉明
英文同义词:
2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxyl pyrazole ketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-one compound with 2-aminoethanol (1:1)
相关类别:
吡啶;乙醇铵盐;分析标准品;化妆品日化原料;化学试剂;医用原料;杀菌剂类;小分子抑制剂;医药原料;农业和环境标准品;日化原料/化妆品;化工原料;精细化工;化工中间体;食品添加剂;有机原料;化妆品原料;吡啶酮乙醇胺盐;OLED materials,pharm chemical,electronic;ARAMINE;bacteriostatic and fungistatic;酮;化工原料-1;化工;医用原料;化工中间体;原料;日化原料;化工原料-1827181813;昆虫信息素;材料中间体;抗菌防腐;精细化工品;化妆品类;医药化学品;PP
InChIKey
BTSZTGGZJQFALU-UHFFFAOYSA-N
CAS 数据库
68890-66-4(CAS DataBase Reference)
简介
吡罗克酮乙醇胺盐独特的性能主要表现在:
1. 去屑止痒效果优于同类产品。
2. 溶解性能、复配性能优良,与化妆品原料混合不会发生沉淀或分层现象。
3. 去屑机理独特,刺激性极低,不会引起脱发、断发,安全性优于同类去屑止痒产品。
用途
羟吡酮是一种高效、无毒无刺激的去屑剂,可以广泛使用于去屑香波、养发液和护发素等洗护类化妆品中。
生物活性
Piroctone olamine 是一种吡啶衍生物。具有杀真菌作用。
体外研究
Piroctone olamine, the ethanolamine salt of the hydroxamic acid derivative Piroctone, is a hydroxypyridone anti-mycotic agent. Piroctone olamine penetrates the cell membrane and forms complexes with iron ions, inhibiting energy metabolism in mitochondria. Piroctone olamine (PO) is an ethanolamine salt of the hydroxamic acid derivative Piroctone. All Candida strains show low minimum inhibitory concentrations (MICs) for Piroctone olamine (0.125-0.5 μg/mL) and Amphotericin B (AMB) (0.03-1 μg/mL).
体内研究
This work aimed to evaluate the antifungal activity of Piroctone olamine in the treatment of intra-abdominal candidiasis in an experimental model using Swiss mice. The treatment with Piroctone olamine (0.5 mg/kg) is performed 72 h after infection by intraperitoneal administration. For comparison, a group of animals (n=6) is treated with Amphotericin B (0.5 mg/kg). The mycological diagnosis is made by collecting the liver, spleen and kidneys. Data regarding the fungal growth and mortality are analyzed statistically by Student’s t test and analysis of variance, with level of significance set at P<0.05. The difference in fungal growth scoring between the control group and the treatment groups (Piroctone olamine and Amphotericin B) is statistically significant (P<0.05).