中文同义词:
山竺提取物;曼果斯廷;1,3,6-三羟基-7-甲氧基-2,8-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮;Α-倒捻子素(标准品);Α-倒捻子素;ALPHA-倒捻子素;楝子素;曼果斯廷对照品,
英文同义词:
α-Mangostin, 98%, from Garcinia mangostana;α-Mangostin (a-Mangostin、ALPHA-Mangostin);α-Mangostin, froM Garcinia Mangostana;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-on;Alpha-Mangostin α-Mangostin;1,3,6-Trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9H-xanthen-9-one;1,3,6-TRIHYDROXY-7-METHOXY-2,8-DI(3-METHYL-2-BUTENYL)XANTHONE;Mangosteen
相关类别:
分析标准品;中药对照品;标准品;植物提取物;中草药成分;标准植物提取物;植提标准品;对照品;植物生化提取物;提取物;医药原料;Xanthones;Intermediates Fine Chemicals;Pharmaceuticals;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance;标准产品;氧杂蒽酮;标准品 -中药标准品;分析试剂-化学分析;标准品,对照品;标准提取物;标准品-对照品;主营推荐产品;植物单体;比例提取物
沸点
640.1±55.0 °C(Predicted)
密度
1.265±0.06 g/cm3(Predicted)
溶解度
methanol: soluble1mg/mL, clear, very light yellow
酸度系数(pKa)
7.22±0.20(Predicted)
最大波长(λmax)
346nm(MeOH)(lit.)
InChIKey
GNRIZKKCNOBBMO-UHFFFAOYSA-N
CAS 数据库
6147-11-1(CAS DataBase Reference)
概述
α-倒捻子素是从植物山竹子中提取的一种氧杂蒽酮类化合物。此外,α-倒捻子素来源于天然山竹子的有效成分,具有安全无毒及悠久食用历史等特点,对α-倒捻子素作为药物的深入研究提供了理论和应用基础。
生物活性
alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮,如抗氧化剂,抗过敏,抗病毒,抗菌,抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂,Ki值为 2.85 μM。
靶点
IC50: 2.85 μM (IDH1-R132H)
体外研究
alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H 2 O 2 -induced apoptosis of RPE cells. 200 μM H 2 O 2 -induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).
体内研究
alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
化学性质
白色结晶粉末,可溶于甲醇、乙醇、DMSO等有机溶剂,来源于藤黄科(Guttiferae)山竹壳、罗汉果、山竺。
用途
α-倒捻子素具有治疗腹泻、疟疾、抗炎、抗溃疡以及抗白血病和败血病的作用。
用途
用于含量测定/鉴定/药理实验等
药理药效:具有抗氧化、抗炎、抗菌、抗癌等药理活性
危险品运输编号
UN 2811 6.1 / PGIII