盐酸替莫普利

中文名称:

盐酸替莫普利

中文同义词:

[(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮杂卓-4-基]乙酸盐酸盐;盐酸替莫普利;替莫普利盐酸盐;TEMOCAPRIL HYDROCHLORIDE盐;盐酸替莫普利及中间体

英文名称:

Temocapril hydrochloride

英文同义词:

TEMOCAPRIL HYDROCHLORIDE;Temocapril HCl and intermediates;Acecol;CS-622;1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI);1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-;Temocapril Hcl;TemocarpileHCL

CAS号:

110221-44-8

分子式:

C23H28N2O5S2.ClH

分子量:

513.076

EINECS号:

1312995-182-4

相关类别:

小分子抑制剂，天然产物;中间体;药物分子;原料;Intermediates Fine Chemicals;Pharmaceuticals;Inhibitors

Mol文件:

110221-44-8.mol

熔点 

196-2000C (dec)

比旋光度 

25D +47.7° (c = 1 in DMF)

储存条件 

-20°C Freezer

CAS 数据库

110221-44-8(CAS DataBase Reference)

生物活性

Temocapril HCl (CS-622)是Temocapril的盐酸盐形式，是一种长效的血管紧张素转换酶（ACE）抑制剂，用于治疗高血压。

靶点

Target Value ACE

Target

Value

ACE

体外研究

Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver.

体内研究

Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney. Animal Model: Male Sprague Dawley rats Dosage: 30 mg/kg Administration: Oral administration, daily, for 4 weeks Result: Suppressed the blood pressure elevation induced by Ang I.

Animal Model:

Male Sprague Dawley rats

Dosage:

30 mg/kg

Administration:

Oral administration, daily, for 4 weeks

Result:

Suppressed the blood pressure elevation induced by Ang I.

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36

毒性

LD50 in mice, rats, dogs (mg/kg): >5000, >5000, >800 orally (Koike)