中文同义词:
FRAXINELLONE 梣酮;梣酮, 来源于白鲜皮;梣桐;梣酮(标准品);3-(3-呋喃基)-3A,4,5,6-四氢-3A,7-二甲基苯酞;酮;Q酮;岑酮/梣酮/秦皮酮
英文同义词:
1(3H)-Isobenzofuranone,3-(3-furanyl)-3a,4,5,6-;tetrahydro-3a,7-dimethyl-,(3R,3aR)- (9CI);(3R)-3β-(3-Furanyl)-3aβ,7-dimethyl-1,3,3a,4,5,6-hexahydroisobenzofuran-1-one;(3R)-3β-(3-Furyl)-3a,4,5,6-tetrahydro-3aβ,7-dimethylisobenzofuran-1(3H)-one;3-(3-Furyl)-3a,4,5,6-tetrahydro-3a,7-dimethylphthalide;(3R,3aR)-3-(3-Furyl)-3a,7-diMethyl-3a,4,5,6-tetrahydro-2-benzofuran-1(3H)-one;1(3H)-Isobenzofuranone,3-(3-furanyl)-3a,4,5,6-tetrahydro-3a,7-diMethyl-,(3R-cis);Fraxinellone
相关类别:
植物药;中药对照品;标准品;对照品,标准品;植物提取物;植提标准品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;对照品;标准品-中药标准品;对照品-中药对照品;三萜;标准品 -中药标准品;分析试剂-对照品;标准品,对照品;标准品-对照品;standardized herbal extract
沸点
314.44°C (rough estimate)
密度
1.1649 (rough estimate)
用途
梣酮是一种杀虫剂,抑制幼虫生长,用于作物和农产品的处理和保护。同时,是一种可用于治疗肿瘤的天然化合物。
生物活性
Fraxinellone 是从芸苔科植物 Dictamnus dasycarpus 的根皮中分离出来的。 Fraxinellone 是 PD-L1 抑制剂,可抑制 HIF-1α 蛋白质合成,而不会影响 HIF-1α 蛋白质降解。 Fraxinellone 通过靶向 PD-L1,有用于癌症免疫的潜能。
体外研究
Fraxinellone (0-100 μM;12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells.
Cell Viability Assay
Cell Line: A549 cells
Concentration: 0 μM, 10 μM, 30 μM, 100 μM
Incubation Time: 12 hours
Result: Inhibited the percent of PD-L1 positive cells.
Concentration:
0 μM, 10 μM, 30 μM, 100 μM
Result:
Inhibited the percent of PD-L1 positive cells.
体内研究
Fraxinellone (oral gavage; 30 and 100 mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice.
Animal Model: BALB/c nude mice
Dosage: 30 and 100 mg/kg
Administration: Oral gavage; 30 and 100 mg/kg; every three days; 30 days
Result: Significantly suppressed tumor growth.
Animal Model:
BALB/c nude mice
Administration:
Oral gavage; 30 and 100 mg/kg; every three days; 30 days
Result:
Significantly suppressed tumor growth.
化学性质
白色结晶粉末,易溶于氯仿、乙酸乙酯,来源于白鲜皮,白柳(Salix alba L.)的皮。
用途
用于含量测定/鉴定/药理实验等。
药理药效:抗生育作用,抗血小板聚集作用,显著的血管松弛作用。选择性的钙通道阻滞作用,且呈电压依赖关系。
危险品运输编号
UN 2811 6.1/PG III