N-乙酰-5-羟色胺

中文名称:

N-乙酰-5-羟色胺

中文同义词:

N-乙酰-5-羟色胺;N-乙酰羟色胺;N-乙酰基血清素;N-乙酰基-5-羟基色胺;N-乙酰-5-羟基色胺;N-乙酰-5-羟基色胺;羟色胺杂质5;N-(2-(5-羟基-1H-吲哚-3-基)乙基)乙酰胺

英文名称:

N-ACETYL-5-HYDROXYTRYPTAMINE

英文同义词:

N-Acetyl-5-hydroxytryptamine, 3-(N-Acetyl-2-aminoethyl)-5-hydroxyindole, 98%;N-Acetyl-5-hydroxytryptamine,N-Acetylserotonin, Normelatonin;3-(2-Acetamidoethyl)-5-hydroxyindole N-Acetylserotonin;N-Acetylserotonin, Normelatonin;Acetylserotonin;N-Acetyl-5-HT;N-Acetyl-5-hydroxy-1H-indole-3-ethaneamine;N-Acetyl-5-hydroxytryptamine,99%

CAS号:

1210-83-9

分子式:

C12H14N2O2

分子量:

218.25

EINECS号:

214-916-5

相关类别:

化学试剂;试剂和补充物;小分子抑制剂;对照品;其他生化试剂;杂环化合物;药物杂质及中间体;Various Metabolites and Impurities;Tryptamines;Amino Acids;Heterocyclic Compounds;Indoles;Intermediates Fine Chemicals;Metabolites Impurities;Pharmaceuticals;Metabolites Impurities, Pharmaceuticals, Intermediates Fine Chemicals

Mol文件:

1210-83-9.mol

熔点 

120-122 °C (lit.)

沸点 

556.8±40.0 °C(Predicted)

密度 

1.268±0.06 g/cm3(Predicted)

储存条件 

2-8°C

溶解度 

ethanol: 50 mg/mL

酸度系数(pKa)

10.09±0.40(Predicted)

形态

powder

颜色

white

CAS 数据库

1210-83-9(CAS DataBase Reference)

生物活性

N-Acetyl-5-hydroxytryptamine (NAS, N-Acetylserotonin, Normelatonin, O-Demethylmelatonin) 是褪黑激素的前体，也是一种有效的 TrkB receptor 的选择性激动剂。

靶点

Target Value TrkB receptor ()

Target

Value

TrkB receptor ()

体外研究

N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.

体内研究

To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.

安全说明 

22-24/25

WGK Germany 

3

海关编码 

29339900