地托咪定

中文名称:

地托咪定

中文同义词:

地托咪定;地拖咪啶;4-(2,3-二甲苄基)-1H-咪唑;美托咪定杂质12;右美托嘧啶杂质D;右美托嘧啶杂质D；4-(2,3-二甲苄基)-1H-咪唑;美托咪定杂质26

英文名称:

4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE

英文同义词:

4-(2,3-DIMETHYL-BENZYL)-1H-IMIDAZOLE;1H-Imidazole, 4-((2,3-dimethylphenyl)methyl)-;4-(2,3-Dimethylbenzyl)imidazol;90038-01-0 (Monohydrochloride);Detomidina;Detomidina [inn-spanish];Detomidine [inn:ban];detomidine

CAS号:

76631-46-4

分子式:

C12H14N2

分子量:

186.25

EINECS号:

相关类别:

杂质对照品;医用原料;医药原料

Mol文件:

76631-46-4.mol

熔点 

114-116°

沸点 

386.5±11.0 °C(Predicted)

密度 

1.077±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

14.44±0.10(Predicted)

生物活性

Detomidine 是一种咪唑衍生物，是一种有效的 α2-肾上腺素能 (α2-adrenergic) 激动剂。Detomidine 产生剂量依赖性的镇静和镇痛作用。

体外研究

Currently, detomidine is only licenced for use in horses. Detomidine is a sedative with analgesic properties. α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters. Due to inhibition of the sympathetic nervous system, detomidine also has cardiac and respiratory effects and an antidiuretic action.

毒性

LD50 i.v. in mice: 35 mg/kg (Karjalayne, Kurkela)