3-(2,6-二氯苯基)-5-甲基-4-异恶唑酰氯

中文名称:

3-(2,6-二氯苯基)-5-甲基异唑-4-甲酰氯

中文同义词:

3-(2,6-二氯苯基)-5-甲基异唑-4-羰基氯;3-(2,6-二氯苯基)-5-甲基异恶唑-4-甲酰氯;3-(2,6-二氯苯基)-5-甲基异唑-4-甲酰氯;3-(2,6-二氯苯基)-5-甲基异恶唑-4-碳酰氯;3-(2,6二氯苯基)-5-甲基异恶唑-4-酰氯;双氯西林侧链;D酰氯;3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE-4-CARBONYL CHLORIDE CAS号:4462-55-9

英文名称:

3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride

英文同义词:

3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarbonylchlorid;3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE-4-CARBONYL CHLORIDE;3-(2,6-Dichlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl chloride;3-(2,6-DICHLOROPHENYL)-5-METHYL-4-CHLOROCARBONYL ISOXAZOLE;3-(2,6-DICHLOROPHENYL)-5-METHYL-4-ISOXAZOLE-CARBONYL CHLORIDE;DICHLOROPHENYL-5-METHYLISOXAZOLE-4-CARBONYLCHLORIDE;3-(2,6-Dichlorophenyl)-5-Methyl-4-Carbonylisoxazolechloride;3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolecarbonyl chlorid 3-(2,6-dichlorophenyl)-5-methylisoxazole- 4-carbonyl chloride 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolecarbonyl chloride

CAS号:

4462-55-9

分子式:

C11H6Cl3NO2

分子量:

290.53

EINECS号:

224-723-8

相关类别:

医药中间体;异恶唑;化工原料;医药生物化工;Aromatics;Heterocycles;OxazoleIsoxazole

Mol文件:

4462-55-9.mol

熔点 

92 °C

沸点 

390.9±42.0 °C(Predicted)

密度 

1.472±0.06 g/cm3(Predicted)

酸度系数(pKa)

-6.62±0.50(Predicted)

CAS 数据库

4462-55-9(CAS DataBase Reference)

EPA化学物质信息

4-Isoxazolecarbonyl chloride, 3-(2,6-dichlorophenyl)-5-methyl- (4462-55-9)

用途 

用作医药中间体

用途 

双氯苯唑青霉素钠的中间体。

生产方法 

用2,6-二氯甲苯以氯气、三氯化磷在紫外线催化下氯化，生成2,6-α,α-四氯甲苯，然后与盐酸羟胺在浓硫酸参与下肟化，得2,6-二氯苯甲肟，再经氯化得2,6-二氯苯甲肟氯，进而与乙酰乙酸乙酯在氢氧化钠作用下环合，生成3-（2，6-二氯苯基）-5-甲基-4-异噁唑甲酸乙酯，最后酯基水解，以五氯化磷氯化羧基制得该品。

危险品标志 

C

危险类别码 

34

安全说明 

26-36/37/39-45-36/37/39/45

危险品运输编号 

3261

Hazard Note 

Corrosive